regulator of G protein signaling 9-binding protein (RGS9-anchoring protein, RGS9BP, R9AP)

Function

• regulates G protein-coupled receptor signaling in phototransduction
• participates to the recovery phase of visual transduction via interaction with RGS9-1 isoform
• acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place
• enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing visual signal to be terminated on a physiological time scale
• controls proteolytic stability of RGS9-1, probably by protecting it from degradation
• component of the RGS9-1-Gbeta5 complex composed of RGS9-1, Gbeta5 (GNB5) & RGS9BP

Structure

belongs to the RGS7BP/RGS9BP family

Compartment

membrane

Pathology

• defects in RGS9BP are a cause of bradyopsia

More general terms

• membrane protein

Additional terms

• regulator of G-protein signaling 9 (RGS9)

Database

• OMIM: https://mirror.omim.org/entry/607814
• OMIM: https://mirror.omim.org/entry/608415
• UniProt: http://www.uniprot.org/uniprot/Q6ZS82.html