NLR family CARD domain-containing protein 4; CARD, LRR, & NACHT-containing protein; clan protein; caspase recruitment domain-containing protein 12; Ice protease-activating factor; Ipaf (NLRC4, CARD12, CLAN, CLAN1, IPAF, UNQ6189/PRO20215)

Function

• plays a role in the promotion of apoptosis
• self-associates & binds to ASC, pro-caspase-1, NOD2, BCL10 & NALP1 (NAC) by CARD-CARD interaction

Structure

• contains 1 CARD domain
• contains 14 LRR repeats (leucine-rich repeats)
• contains 1 NACHT domain

Compartment

cytoplasm. Note: cytoplasmic filaments

Alternative splicing

named isoforms=4

Expression

• isoform 2
  • expressed ubiquitously
  • highly expressed in lung & spleen
• isoform 1
  • expressed in lung > leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow & fetal liver
• isoform 4 is only detected in brain

More general terms

• caspase recruitment domain protein (CARD protein)
• leucine-rich repeat-containing protein (LRRC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=58484
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:58484
• OMIM: https://mirror.omim.org/entry/606831
• UniProt: http://www.uniprot.org/uniprot/Q9NPP4.html