enkurin (ENKUR, C10orf630)

Function

• adapter
• localizes Ca+2-sensitive signal transduction machinery in sperm to a Ca+-permeable ion channel
• binds calmodulin via its IQ domain
• interacts with TRPC1, TRPC2, TRPC5, but not TRPC3

Structure

• contains 1 IQ domain
• IQ motif is involved in calmodulin binding
• residues 160-255 contains the TRPC2 binding site

Compartment

• cell projection, cilium, flagellum
• sperm acrosomal crescent & flagellar principal piece

More general terms

• testis-specific protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8TC29.html