activating signal cointegrator 1; ASC-1; thyroid receptor-interacting protein 4; TR-interacting protein 4; TRIP-4 (TRIP4)

Function

• transcription coactivator of nuclear receptors
• acts in conjunction with CBP-p300 & SRC-1
• occurs as a steady-state complex associated with activating signal cointegrator 1 complex.
• interacts with the ligand binding domain of thyroid receptor
• mediator of transrepression between nuclear receptor & either AP1 or NF-kappa-B
• role in androgen receptor transactivation & in testicular function (putative)
• specifically interacts with the ligand binding domain of the thyroid hormone receptor; interaction requires presence of thyroid hormone
• exists as a steady-state complex associated with ASCC1, ASCC2 & HELIC1
• interacts with androgen receptor (androgen-dependent)

Compartment

• nucleus, cytoplasm.
• cytoplasmic under conditions of serum deprivation

More general terms

• thyroid hormone receptor interacting protein (TRIP)
• zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9325
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9325
• OMIM: https://mirror.omim.org/entry/604501
• UniProt: http://www.uniprot.org/uniprot/Q15650.html