autophagy protein 10-like; ubiquitin-like-conjugating enzyme ATG10; autophagy-related protein 10; APG10-like (ATG10, APG10L, pp12616)

Function

• E2-like enzyme involved in autophagy
• acts as an E2-like enzyme that catalyzes conjugation of ATG12 to ATG5
• ATG12 conjugation to ATG5 is required for autophagy
• likely serves as an ATG5-recognition molecule
• not involved in ATG12 conjugation to ATG3 (putative)
• interacts with MAP1LC3A
  • by interacting with MAP1LC3A, it plays a role in conjugation of ATG12 to ATG5
• also able to directly interact either with ATG5 or ATG7 (putative)

Structure

belongs to the ATG10 family

Compartment

cytoplasm (probable)

Alternative splicing

named isoforms=2

More general terms

• autophagy protein (autophagy-related protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83734
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:83734
• OMIM: https://mirror.omim.org/entry/610800
• UniProt: http://www.uniprot.org/uniprot/Q9H0Y0.html