amyloid beta A4 protein-binding family A member 3; neuron-specific X11L2 protein; neuronal Munc18-1-interacting protein 3; mint-3; adapter protein X11gamma (APBA3, MINT3, X11L2)

Function

• may modulate processing of beta-amyloid precursor protein (APP) & thus formation of beta-APP
• binds to the cytoplasmic domain of amyloid protein (APP) in vivo

Structure

• domains
  • N-terminal domain
  • a middle phospho-Tyr-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein,
  • two C-terminal PDZ domains thought to attach proteins to the plasma membrane
• contains 2 PDZ domain (DHR domain)s
• contains 1 PID domain

Expression

• expressed in all the tissues examined
• lower levels in brain & testis

More general terms

• amyloid beta A4 precursor protein binding family
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9546
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9546
• OMIM: https://mirror.omim.org/entry/604262
• UniProt: http://www.uniprot.org/uniprot/O96018.html