Wiskott-aldrich syndrome protein family member 3; WASP family protein member 3; protein WAVE-3; verprolin homology domain-containing protein 3 (WASF3, KIAA0900, SCAR3, WAVE3)

Function

• downstream effector involved in signal transduction from tyrosine kinase receptors & small GTPases to the actin cytoskeleton
• binds actin & the Arp2/3 complex
• required in the control of cell shape
• interacts with ABI2, KIFC3, RASL3, KANK2 & BYST

Structure

• binds the Arp2/3 complex through the C-terminal region & actin through verprolin homology (VPH) domain
• belongs to the SCAR/WAVE family
• contains 1 WH2 domain

Compartment

cytoplasm, cytoskeleton

Expression

expressed in ovary & brain

Pathology

• may be overexpressed in chronic fatigue syndrome
  • overexpression
    • can disrupt mitochondrial respiratory supercomplex formation
    • is associated with endoplasmic reticulum stress
    • associated with reduced complex IV levels in skeletal muscle mitochondria

More general terms

• Wiskott Aldrich syndrome protein family (WASF)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10810
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10810
• OMIM: https://mirror.omim.org/entry/605068
• UniProt: http://www.uniprot.org/uniprot/Q9UPY6.html