bystin; by the ribosomal protein s6 gene, drosophila, homolog-like (BYSL, BYST)

Function

• required for processing of 20S pre-rRNA precursor & biogenesis of 40S ribosomal subunits
• may function with trophinin & tastin in cell adhesion mediating attachment of the blastocyst to uterine epithelial cells during embryo implantation
• binds trophinin, tastin & cytokeratins

Structure

• belongs to the bystin family

Compartment

• cytoplasm., nucleus, nucleolus
• associated with 40S ribosomal subunits

Expression

• found in the placenta from the 6th week of pregnancy
• localized in the cytoplasm of syncytiotrophoblast in the chorionic villi & in endometrial decidual cells at the uteroplacental interface
• after week 10, expression decreases & then disappears from placental villi

Notes

• HeLa cells lacking BYSL show a delay in the processing of the 18S rRNA component of the 40S ribosomal subunit
• HT-H cells lacking BYSL show trophinin-independent signaling through ERBB4

More general terms

• protein subunit
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=705
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:705
• OMIM: https://mirror.omim.org/entry/603871
• UniProt: http://www.uniprot.org/uniprot/Q13895.html