SH3 domain-binding protein 5; SH3BP-5; SH3 domain-binding protein that preferentially associates with BTK (SH3BP5, SAB)

Function

• inhibits the protein kinase activity of BTK
• inhibitory regulatory role in BTK-related cytoplasmic signaling in B-cells
• may be involved in BCR-induced apoptotic cell death
• interacts with all isoforms of MAPK8, MAPK9, MAPK10 & MAPK12

Structure

belongs to the SH3BP5 family

Compartment

mitochondria

Alternative splicing

named isoforms=2

Expression

• highly expressed in testis & ovaries
• also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine & prostate

More general terms

• SH3 domain-binding protein
• phosphoprotein
• mitochondrial protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9467
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9467
• OMIM: https://mirror.omim.org/entry/605612
• UniProt: http://www.uniprot.org/uniprot/O60239.html