dual specificity tyrosine-phosphorylation-regulated kinase 3; regulatory erythroid kinase; REDK (DYRK3)

Function

• negative regulator of EPO-dependent erythropoiesis
• may place an upper limit on red cell production during stress erythropoiesis
• inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells
• may act by regulating CREB/CRE signaling
• autophosphorylated on Tyr

Cofactor: Mg+2 (putative)

Structure

• belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily
• contains 1 protein kinase domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• isoform 1 & isoform 2 are highly expressed in testis & in hematopoietic tissue such as fetal liver, & bone marrow
• isoform 2 is the predominant form in testis
• isoform 1 is the predominant form in fetal liver & bone marrow
• isoform 1 & isoform 2 are present at low levels in heart, pancreas, lymph node, & thymus
• induced by EPO/erythropoietin

More general terms

• dual-specificity tyrosine-phosphorylation regulated kinase
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8444
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8444
• OMIM: https://mirror.omim.org/entry/603497
• UniProt: http://www.uniprot.org/uniprot/O43781.html