activin receptor type-1; activin receptor type I; ACTR-I; serine/threonine protein kinase receptor R1; SKR1; activin receptor-like kinase 2; ALK-2; TGF-B superfamily receptor type I; TSR-I (ACVR1, ACVRLK2)

Function

• receptor for activin
• on ligand binding, forms a receptor complex consisting of 2 type II & 2 type I transmembrane serine/threonine kinases
• type II receptors phosphorylate & activate type I receptors which autophosphorylate, then bind & activate SMAD transcriptional regulators
• may be involved in left-right pattern formation during embryogenesis

Cofactor: Mg+2 or Mn+2 (putative)

Structure

• belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
• contains 1 GS domain
• contains 1 protein kinase domain

Compartment

membrane

Expression

• expressed in normal parenchymal cells, endothelial cells, fibroblasts

Pathology

• expressed in tumor-derived epithelial cells
• defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva

More general terms

• activin receptor
• activin receptor like kinase (ALK)
• phosphoprotein
• glycoprotein

More specific terms

• activin receptor 1C; ACTR-IC; activin receptor-like kinase 7; ALK-7 (ACVR1C, ALK7)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:90
• OMIM: https://mirror.omim.org/entry/102576
• OMIM: https://mirror.omim.org/entry/135100
• UniProt: http://www.uniprot.org/uniprot/Q04771.html