activin receptor 1C; ACTR-IC; activin receptor-like kinase 7; ALK-7 (ACVR1C, ALK7)

Function

• serine/threonine protein kinase
• forms a receptor complex* on ligand binding
• plays a role in cell differentiation, growth arrest & apoptosis
• binds & activates SMAD2 & SMAD3
• receptor for activin AB, activin B & NODAL

* receptor complex consists of two type 2 & two type 1 transmembrane serine/threonine kinases. Type 2 receptors phosphorylate & activatetype 1 receptors which autophosphorylate

Structure

• belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
• contains 1 GS domain
• contains 1 protein kinase domain

Compartment

membrane

Alternative splicing

named isoforms=4

Expression

• expressed in pancreas, heart, colon, small intestine, ovary, hippocampus, medulla oblongata & putamen
• isoforms 1-4 are all expressed in the placenta throughout pregnancy

More general terms

• activin receptor type-1
• serine/threonine kinase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1303
• OMIM: https://mirror.omim.org/entry/608981
• UniProt: http://www.uniprot.org/uniprot/Q8NER5.html