ribosomal S6 kinase-1 (ribosomal protein S6 kinase alpha 1, S6K-alpha 1, 90 kD ribosomal protein S6 kinase 1, p90-RSK 1, RSK-1, pp90RSK1, RPS6KA1)

Function

• serine/threonine kinase that may play a role in mediating growth-factor & stress induced activation of the transcription factor CREB
• forms a complex with either ERK1 or ERK2 in quiescent cells
• transiently dissociates following mitogenic stimulation activated by multiple phosphorylations on Thr & Ser
• autophosphorylated on Ser-380, as part of the activation process
• activated in cells incubated with insulin, but apparently not a substrate for MAP kinase

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
• contains 1 AGC-kinase C-terminal domain
• contains 2 protein kinase domains

More general terms

• ribosomal protein S6 kinase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6195
• OMIM: https://mirror.omim.org/entry/601684
• UniProt: http://www.uniprot.org/uniprot/Q15418.html