tumor necrosis factor receptor superfamily member 21; TNFR-related death receptor 6; Death receptor 6 (TNFRSF21 DR6 UNQ437/PRO868)

Function

• may activate NF-kappa-B & JNK & promote apoptosis
• associates with TRADD

Structure

• contains 1 death domain
• contains 4 TNFR-Cys repeats

Compartment

membrane

Expression

• highly expressed in heart, brain, placenta, pancreas, lymph node, thymus & prostate
• detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow & fetal liver
• very low levels were found in adult liver & peripheral blood leukocytes

Notes

uncertain whether Met-1 or Met-25 is the initiator

More general terms

• tumor necrosis factor [TNF] receptor family
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2724
• OMIM: https://mirror.omim.org/entry/605732
• UniProt: http://www.uniprot.org/uniprot/O75509.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27242