G-protein coupled receptor family C group 5 member C; retinoic acid-induced gene 3 protein; RAIG-3 (GPRC5C RAIG3 PSEC0087)

Function

• retinoic acid-inducible G-protein coupled receptor
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

belongs to the G-protein coupled receptor 3 family

Compartment

• cell membrane
• cytoplasmic vesicle membrane
• localized in the plasma membrane & perinuclear vesicles
• multi-pass membrane protein

Alternative splicing

named isoforms=2

Expression

• expression is highest in the stomach, kidney, liver, pancreas, & prostate
• in brain
  • expression is generally lower than in the periphery
  • highest expression in cerebellum
• expressed in spinal cord, & dorsal root ganglia (DRG)
• induced by all-trans retinoic acid (ATRA)

Notes

• GPRC5C may provide evidence for interaction(s) between retinoid(s) & G-protein signaling pathway(s)

More general terms

• G-protein coupled receptor; serpentine receptor
• phosphoprotein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55890
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55890
• OMIM: https://mirror.omim.org/entry/605949
• UniProt: http://www.uniprot.org/uniprot/Q9NQ84.html