prokineticin receptor 2; PK-R2; G protein-coupled receptor 73-like 1 (PROKR2, GPR73b, GPRg2, GPR73L1, PKR2)

Function

• receptor for prokineticin 2
• exclusively coupled to Gq proteins
• activation leads to mobilization of Ca+2, stimulation of phosphoinositide turnover & activation of p44/p42 mitogen-activated protein kinase

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• expressed in the ileocecum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary & brain

Pathology

• defects in PROKR2 are the cause of Kallmann syndrome type 3

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1286
• OMIM: https://mirror.omim.org/entry/244200
• OMIM: https://mirror.omim.org/entry/607123
• UniProt: http://www.uniprot.org/uniprot/Q8NFJ6.html