prokineticin-2 (PK2, protein Bv8 homolog, PROK2, BV8)

Function

• output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm
• role locally within the SCN to synchronize output
• contracts gastrointestinal (GI) smooth muscle

Structure

• belongs to the AVIT (prokineticin) family

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

• expressed in the testis > small intestine
• activated by CLOCK & BMAL1 heterodimers & light
• inhibited by period genes (PER1, PER2 & PER3) & cryptochrome genes (CRY1 & CRY2)

More general terms

• secreted protein

Additional terms

• suprachiasmatic nucleus

Database

• OMIM: https://mirror.omim.org/entry/607002
• UniProt: http://www.uniprot.org/uniprot/Q9HC23.html