period circadian protein homolog 3; hPER3; cell growth-inhibiting gene 13 protein; circadian clock protein PERIOD 3 (PER3)

Function

• component of the circadian clock mechanism which is essential for generating circadian rhythms
• function unknown
• phosphorylation appears to require association with PER1 & translocation to the nucleus (putative)
• ubiquitinated (putative)
• homodimer.
• component of the circadian core oscillator
  • interacts directly with PER1, PER2, CRY1, CRY2, & TIMELESS
  • interaction with CSNK1D or CSKN1E promotes nuclear location of PER proteins

Structure

• contains 1 PAC (PAS-associated C-terminal) domain
• contains 2 PAS (PER-ARNT-SIM) domains

Compartment

• cytoplasm (putative), nucleus
• mainly cytoplasmic
• translocates to the nucleus through binding PER1, PER2, CRY1 or CRY2
• binding to TIMELESS does not lead to nuclear translocation

Alternative splicing

named isoforms=2

More general terms

• period circadian protein (hPER)

Component of

• circadian core oscillator

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8863
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8863
• OMIM: https://mirror.omim.org/entry/603427
• UniProt: http://www.uniprot.org/uniprot/P56645.html