casein kinase 1 delta (CSNK1D)

Function

• participates in Wnt signaling
• central component of the circadian core oscillator & circadian clock
• may act as a negative regulator of circadian rhythmicity by phosphorylating PER1 & PER2, leading to their degradation
• retains PER1 in the cytoplasm
• exhibits substrate-dependent heparin activation
• autophosphorylated on Ser & Thr

Structure

• monomer.
• belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family, casein kinase 1 subfamily
• contains 1 protein kinase domain

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta & skeletal muscle
• in blood, highly expressed in hemopioetic cells & mature granulocytes, also found in monocytes & lymphocytes

Pathology

• defects in CSNK1D are a cause of familial advanced sleep-phase syndrome

More general terms

• casein kinase 1

Database

• UniProt: http://www.uniprot.org/uniprot/P48730.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1453
• OMIM: https://mirror.omim.org/entry/600864
• OMIM: https://mirror.omim.org/entry/604348
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1453