G protein-coupled receptor for asthma susceptibility (G-protein coupled receptor 154, vasopression-related receptor 1, neuropeptide S receptor, G-protein coupled receptor PGR14, NPSR1, GPR154, VPR1, GPRA, PGR14)
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Function
- autocrine or paracrine signaling
- receptor for neuropeptide S
Structure
belongs to the G-protein coupled receptor 1 family
Compartment
- isoforms 1,3,4: cell membrane
- isoforms 2,5,6,7,9: cytoplasm
Alternative splicing
named isoforms=9
Expression
ubiquitously expressed
Pathology
- involved in pathogenesis of asthma and other IgE-mediated disease
- NPSR1 is associated with susceptibility to asthma & elevated serum IgE levels
- polymorphisms may influence the development of asthma
- associated with allergic sensitization, rhinoconjunctivis, & asthma
More general terms
References
- ↑ OMIM https://mirror.omim.org/entry/608595
- ↑ Journal Watch 24(11):91, 2004 a) Laitinen T, Polvi A, Rydman P, Vendelin J, Pulkkinen V, Salmikangas P, Makela S, Rehn M, Pirskanen A, Rautanen A, Zucchelli M, Gullsten H, Leino M, Alenius H, Petays T, Haahtela T, Laitinen A, Laprise C, Hudson TJ, Laitinen LA, Kere J. Characterization of a common susceptibility locus for asthma- related traits. Science. 2004 Apr 9;304(5668):300-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15073379 b) Couzin J. Genetics. Two new asthma genes uncovered. Science. 2004 Apr 9;304(5668):185-7. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15073340
- ↑ UniProt http://www.uniprot.org/uniprot/Q6W5P4.html
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/gpr154/