serotonin [5HT]-6 receptor; 5-hydroxytryptamine receptor 6; 5-HT-6; serotonin receptor 6 (HTR6)

Function

• one of several receptors for 5-hydroxytryptamine (serotonin)
• activity is mediated by G proteins that stimulate adenylate cyclase (Gs protein)
• high affinity for tricyclic psychotropic drugs
• controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity
• activator of TOR signaling
• interacts with MTOR, RPTOR & NF1
• interacts with CDK5 (putative)

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• expressed in several human brain regions, most prominently in the caudate nucleus

Pharmacology

• idalopirdine, a 5HT6 receptor antagonist, failed to slow cognitive decline in patients with Alzheimer's disease

More general terms

• G-protein coupled receptor; serpentine receptor
• serotonin [5HT] receptor
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3362
• OMIM: https://mirror.omim.org/entry/601109
• UniProt: http://www.uniprot.org/uniprot/P50406.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3362