diencephalon/mesencephalon homeobox protein 1 (paired-like homeobox protein DMBX1, orthodenticle homolog 3, DMBX1, MBX, OTX3, PAXB)

Function

• transcriptional repressor
• represses OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence
• brain development
• homodimer or heterodimer
  • forms heterodimers with OTX2

Structure

• belongs to the paired homeobox family
• contains 1 homeobox DNA-binding domain
• contains 1 OAR domain

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• homeobox protein

Database

• OMIM: https://mirror.omim.org/entry/607410
• UniProt: http://www.uniprot.org/uniprot/Q8NFW5.html