homeobox protein OTX2; orthodenticle homolog 2 (OTX2)

Function

• probably plays a role in the development of the brain & the sense organs
• can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'

Structure

• belongs to the paired homeobox family, bicoid subfamily
• contains 1 homeobox DNA-binding domain

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2

Expression

• expressed in brain
• expressed in embryo

Pathology

• defects in OTX2 are the cause of syndromic microphthalmia 5

More general terms

• homeobox protein

Database

• UniProt: http://www.uniprot.org/uniprot/P32243.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5015
• OMIM: https://mirror.omim.org/entry/600037