sulfotransferase 4A1; ST4A1; brain sulfotransferase-like protein; hBR-STL; hBR-STL-1; nervous system sulfotransferase; NST (SULT4A1, SULTX3)

Function

• catalyzes sulfation of xenobiotics, hormones, & neurotransmitters. displays
• activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphtylamine, & 2-naphtol
• may have a role in sulfation of drugs & neurotransmitters in the CNS

Structure

belongs to the sulfotransferase 1 family

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=2

Expression

• adult
  • expressed in brain, cerebellum & hypothalamus, but not in other tissues, including: pancreas, liver, lung, heart, intestine, spleen, kidney, uterus, adrenal, thymus, epididymis
• fetus
  • highly expressed in fetal brain & occipital lobe
  • less expression in the whole brain, frontal lobe, hippocampus, & lung
  • very low expression in cerebellum, medulla oblongata, temporal lobe, testis, kidney & appendix

More general terms

• sulfotransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25830
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:25830
• OMIM: https://mirror.omim.org/entry/608359
• UniProt: http://www.uniprot.org/uniprot/Q9BR01.html