methyltransferase NSUN5 (NOL1/NOP2/Sun domain family member 5, NOL1R, Williams-Beuren syndrome chromosomal region 20A protein, NSUN5, WBSCR20, WBSCR20A)

Function

• S-adenosyl-L-methionine-dependent methyltransferase activity
• isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the methyltransferase superfamily, RsmB/NOP family

Alternative splicing

named isoforms=3

Expression

• ubiquitous
• detected in placenta, heart, skeletal muscle

More general terms

• methyltransferase

Database

• UniProt: http://www.uniprot.org/uniprot/Q96P11.html