glucosamine-fructose-6-phosphate aminotransferase [isomerizing] 1; D-fructose-6-phosphate amidotransferase 1; glutamine:fructose-6-phosphate amidotransferase 1; GFAT 1; GFAT1; hexosephosphate aminotransferase 1 (GFPT1, GFAT, GFPT)

Function

• controls the flux of glucose into the hexosamine pathway
• catalyzes formation of glucosamine-6-phosphate from fructose-6-phosphate & glutamine
• most likely involved in regulating the availability of precursors for N- & O-linked glycosylation of proteins
• nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate

Structure

• contains 1 glutamine amidotransferase type-2 domain
• contains 2 SIS domains

Alternative splicing

named isoforms=2

Expression

• isoform 1 is predominantly expressed in skeletal muscle
• not expressed in brain
• seems to be selectively expressed in striated muscle

More general terms

• aminotransferase
• phosphoprotein

Additional terms

• glucosamine-fructose-6-phosphate aminotransferase [isomerizing] 2; D-fructose-6-phosphate amidotransferase 2; glutamine:fructose 6 phosphate amidotransferase 2; GFAT 2; GFAT2; hexosephosphate aminotransferase 2 (GFPT2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2673
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2673
• OMIM: https://mirror.omim.org/entry/138292
• UniProt: http://www.uniprot.org/uniprot/Q06210.html