glucosamine-fructose-6-phosphate aminotransferase [isomerizing] 2; D-fructose-6-phosphate amidotransferase 2; glutamine:fructose 6 phosphate amidotransferase 2; GFAT 2; GFAT2; hexosephosphate aminotransferase 2 (GFPT2)

Function

• controls the flux of glucose into the hexosamine pathway
• most likely involved in regulating availability of precursors for N- & O-linked glycosylation of proteins

L-glutamine + D-fructose 6-phosphate
          <-->
L-glutamate + D-glucosamine 6-phosphate

• nucleotide-sugar biosynthesis
  • UDP-N-acetyl-alpha-D-glucosamine biosynthesis
  • alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1

Structure

• contains 1 glutamine amidotransferase type-2 domain
• contains 2 SIS domains

Expression

• highest expression in heart, placenta, & spinal cord

More general terms

• amidotransferase
• phosphoprotein

Additional terms

• glucosamine-fructose-6-phosphate aminotransferase [isomerizing] 1; D-fructose-6-phosphate amidotransferase 1; glutamine:fructose-6-phosphate amidotransferase 1; GFAT 1; GFAT1; hexosephosphate aminotransferase 1 (GFPT1, GFAT, GFPT)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9945
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9945
• OMIM: https://mirror.omim.org/entry/603865
• UniProt: http://www.uniprot.org/uniprot/O94808.html