ankyrin repeat & SOCS box-containing protein 18 (ASB-18, ASB18)

Function

• may be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins
• protein degradation; protein ubiquitinylation

Structure

• SOCS box domain mediates the interaction with Elongin BC complex, an adapter module in different E 3 ubiquitin-protein ligase complexes (putative)
• contains 6 ANK repeats
• contains 1 SOCS box domain

Alternative splicing

named isoforms=2

More general terms

• Ankyrin repeat & SOCS box protein (ASB)

Database

• UniProt: http://www.uniprot.org/uniprot/Q6ZVZ8.html