ankyrin repeat & SOCS box protein 4; ASB-4 (ASB4)

Function

• probable substrate-recognition component of an elongin-Cullin-SOCS-box protein (ECS) E3 ligase complex which mediates the ubiquitination & subsequent proteasomal degradation of target proteins
• promotes differentiation & maturation of the vascular lineage by an oxygen-dependent mechanism (putative)
• protein modification; protein ubiquitination
• hydroxylation at Asn-246 by HIF1AN may provide an oxygen- dependent regulation mechanism for the function of ASB4 in promoting vascular differentiation (putative)
• interacts with HIF1AN
• component of ECS(ASB4) complex

Structure

• the SOCS box domain mediates interaction with the elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (putative)
• contains 6 ANK repeats
• contains 1 SOCS box domain

Alternative splicing

named isoforms=2

More general terms

• Ankyrin repeat & SOCS box protein (ASB)

Additional terms

• Notch/ankyrin repeat
• SOCS box domain

Component of

• ECS(ASB4) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51666
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51666
• OMIM: https://mirror.omim.org/entry/605761
• UniProt: http://www.uniprot.org/uniprot/Q9Y574.html