ankyrin repeat & SOCS box protein 3; ASB-3 (ASB3)

Function

• probable substrate-recognition component of an elongin-Cullin-SOCS-box protein (ECS) E3 ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins
• recognizes TNFRSF1B
• protein modification; protein ubiquitination
• interacts with TCEB2 & TNFRSF1B

Structure

• the SOCS box domain mediates the interaction with the elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (putative)
• contains 11 ANK repeats contains 1 SOCS box domain

Alternative splicing

named isoforms=2

More general terms

• Ankyrin repeat & SOCS box protein (ASB)

Additional terms

• Notch/ankyrin repeat
• SOCS box domain

Component of

• ECS complex; elonginB/C-CUL2/5-SOCS-box protein complex; ECS E3 ubiquitin-protein ligase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51130
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51130
• OMIM: https://mirror.omim.org/entry/605760
• UniProt: http://www.uniprot.org/uniprot/Q9Y575.html