delta-like protein 4; Drosophila delta homolog 4; delta4 (DLL4)

Function

• plays a role in the notch signaling pathway
• activates notch-1 & notch-4 (putative)
• ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis & subsequent degradation (putative)
• binds to notch-1 & notch-4 (putative)
• possibly involved in regulation of vascular biology

Structure

• the delta-Serrate-Lag2 (DSL) domain is required for binding to the notch receptor
• contains 1 DSL domain
• contains 8 EGF-like domains

Compartment

• membrane; single-pass type 1 membrane protein (probable)

Expression

• expressed in vascular endothelium

More general terms

• delta homolog protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54567
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54567
• OMIM: https://mirror.omim.org/entry/605185
• UniProt: http://www.uniprot.org/uniprot/Q9NR61.html