granulysin; lymphokine LAG-2; protein NKG5; T-cell activation protein 519 (GNLY, LAG2, NKG5, TLA519)

Function

• antimicrobial protein that kills intracellular pathogens
• active against a broad range of microbes, including Gram-positive bacteria & Gram-negative bacteria, fungi, & parasites
• kills Mycobacterium tuberculosis
• a 9 kD form is produced by proteolytic processing of a 15 kD protein

Structure

contains 1 saposin B-type domain

Compartment

• secreted
• located in the cytotoxic granules of T-cells, which are released upon antigen stimulation

Alternative splicing

named isoforms=2

Expression

• expressed in natural killer & T-cells
• induced by T-cell growth factor & IL2

More general terms

• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10578
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10578
• OMIM: https://mirror.omim.org/entry/188855
• UniProt: http://www.uniprot.org/uniprot/P22749.html