saposin B; sphingolipid activator protein-1; SAP-1; dispersin; sulfatide/GM1 activator

Function

• saposin-B stimulates the hydrolysis of
  • galactocerebroside sulfate by arylsulfatase A,
  • GM1 gangliosides by beta-galactosidase
  • globotriaosylceramide by alpha-galactosidase A
• saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases

Structure

homodimer

More general terms

• saposin