feline leukemia virus subgroup C receptor-related protein 2; Ca+2-chelate transporter (CCT, FLVCR2, C14orf58)

Function

• transporter specific for a Ca+2-chelator complex
• growth & Ca+2 metabolism
• acts as an importer of heme

Structure

• belongs to the major facilitator superfamily, Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family

Compartment

cell membrane; multi-pass membrane protein

Expression

• expressed in hematopoietic tissues
  • fetal liver, spleen, lymph node, thymus, leukocytes & bone marrow
• expressed in non-hematopoietic tissues
  • brain, placenta, lung, liver & kidney
• expressed in acidophil cells of the pituitary that secrete growth hormone & prolactin

Pathology

• defects FLVCR2 associated with: proliferative vasculopathy & hydranencephaly syndrome

More general terms

• transmembrane 12 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55640
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55640
• OMIM: https://mirror.omim.org/entry/225790
• OMIM: https://mirror.omim.org/entry/610865
• UniProt: http://www.uniprot.org/uniprot/Q9UPI3.html