feline leukemia virus subgroup C receptor-related protein 2; Ca+2-chelate transporter (CCT, FLVCR2, C14orf58)

From Aaushi

Jump to navigation Jump to search

^[1]^[2]

Function

transporter specific for a Ca+2-chelator complex
growth & Ca+2 metabolism
acts as an importer of heme
FLVCR2 is a blood-brain barrier choline transporter responsible for the most of the choline uptake into the brain^[2]

Structure

belongs to the major facilitator superfamily, Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family

Compartment

cell membrane; multi-pass membrane protein

Expression

expressed in hematopoietic tissues
- fetal liver, spleen, lymph node, thymus, leukocytes & bone marrow
expressed in non-hematopoietic tissues
- brain, placenta, lung, liver & kidney
expressed in acidophil cells of the pituitary that secrete growth hormone & prolactin

Pathology

defects FLVCR2 associated with: proliferative vasculopathy & hydranencephaly syndrome

More general terms

choline transporter

References

↑ UniProt http://www.uniprot.org/uniprot/Q9UPI3.html
↑ ^2.0 ^2.1 Cater RJ, Mukherjee D, Gil-Iturbe E et al Structural and molecular basis of choline uptake into the brain by FLVCR2. bioRxiv [Preprint]. 2023 Oct 5:2023.10.05.561059 PMID: https://www.ncbi.nlm.nih.gov/pubmed/37873173 PMCID: PMC10592973 Free PMC article. Preprint. Nature. 2024. May 1 PMID: https://www.ncbi.nlm.nih.gov/pubmed/38693257 https://www.nature.com/articles/s41586-024-07326-y

Database

Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55640
Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55640
OMIM: https://mirror.omim.org/entry/225790
OMIM: https://mirror.omim.org/entry/610865
UniProt: http://www.uniprot.org/uniprot/Q9UPI3.html

Retrieved from "https://aaushi.info/w/index.php?title=A127690&oldid=1204179"

↑ Back to top