ceramide synthase 2; cerS2; LAG1 longevity assurance homolog 2; SP260; tumor metastasis-suppressor gene 1 protein (CERS2 LASS2 TMSG1)

Function

• suppresses growth of cancer cells
• may be involved in sphingolipid synthesis
• interacts with ATP6V0C, ASGR1, ASGR2 & SLC22A1/OCT1
• interacts with ELOV1, HSD17B12 & TECR

Structure

• contains 1 homeobox DNA-binding domain
• contains 1 TLC (TRAM/LAG1/CLN8) domain

Compartment

• nuclear membrane
• endoplasmic reticulum membrane
• multi-pass membrane protein (putative)

Expression

• expressed in kidney, liver, brain, heart, placenta & lung

More general terms

• transmembrane 6e protein
• phosphoprotein
• glycoprotein
• nuclear protein

Additional terms

• metastasis

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29956
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:29956
• OMIM: https://mirror.omim.org/entry/606920
• UniProt: http://www.uniprot.org/uniprot/Q96G23.html