17-beta-hydroxysteroid dehydrogenase 12 (estradiol 17-beta-dehydrogenase 12, 17-beta-HSD 12, 3-ketoacyl-CoA reductase, KAR, HSD17B12)

Function

• biosynthesis of estrogens
• fatty acid biosynthesis
• catalyzes the transformation of estrone to estradiol (major enzyme responsible for this conversion in women)
• 3-ketoacyl-CoA reductase activity
  • reduces both long chain 3-ketoacyl-CoAs & long chain fatty acyl-CoA
  • long fatty acid elongation

Compartment

endoplasmic reticulum membrane

Expression

• expressed in most tissues
• highly expressed in the ovary, breast, expressed in platelets

More general terms

• 17 beta-hydroxysteroid dehydrogenase
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q53GQ0.html