asialoglycoprotein receptor 1; ASGP-R 1; ASGPR 1; hepatic lectin H1 (ASGR1)

Function

• mediates endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed (asialoglycoprotein)
• receptor recognizes terminal galactose & N-acetylgalactosamine units
• Ca+2 is required for ligand binding
• after ligand binding, the receptor-ligand complex is internalized & transported to a sorting organelle, where receptor & ligand are disassociated
• the receptor then returns to the cell membrane surface
• interacts with LASS2
• phosphorylated on a cytoplasmic Ser

Structure

contains 1 C-type lectin domain

Compartment

membrane

Expression

• expressed exclusively in hepatic parenchymal cells

More general terms

• asialoglycoprotein receptor
• Ca+2 binding protein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:432
• OMIM: https://mirror.omim.org/entry/108360
• UniProt: http://www.uniprot.org/uniprot/P07306.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=432