asialoglycoprotein receptor 1; ASGP-R 1; ASGPR 1; hepatic lectin H1 (ASGR1)
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Function
- mediates endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed (asialoglycoprotein)
- receptor recognizes terminal galactose & N-acetylgalactosamine units
- Ca+2 is required for ligand binding
- after ligand binding, the receptor-ligand complex is internalized & transported to a sorting organelle, where receptor & ligand are disassociated
- the receptor then returns to the cell membrane surface
- interacts with LASS2
- phosphorylated on a cytoplasmic Ser
Structure
contains 1 C-type lectin domain
Compartment
membrane
Expression
- expressed exclusively in hepatic parenchymal cells
Pathology
- plasma ASGR1 associated with loneliness[3]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P07306.html
- ↑ Functional glycomics gateway - glycan binding Note: hepatic asialoglycoprotein receptor subunit 1 http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_215
- ↑ 3.0 3.1 Shen C, Zhang R, Yu J, Sahakian BJ, Cheng W, Feng J. Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality. Nat Hum Behav. 2025 Jan 3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39753750