leptin receptor gene-related protein; leptin receptor overlapping transcript protein; OB-R gene-related protein; OB-RGRP (LEPROT, LEPR, OBR)

Function

• negatively regulates leptin receptor (LEPR) cell surface expression, & thus decreases response to leptin
• negatively regulates growth hormone receptor cell surface expression in liver
• may play a role in liver resistance to growth hormone during periods of reduced nutrient availability
• interacts with LEPR (putative)

Structure

• belongs to the OB-RGRP/VPS55 family

Compartment

• Golgi membrane
• endosome membrane

Expression

• expressed at the highest levels in heart & placenta
• lesser expression in lung, liver, skeletal muscle, kidney & pancreas

Notes

• protein is encoded by LEPR gene, but shares with LEPR only the 1st two 5'-UTR exons
• this it does not share any sequence similarity with LEPR

More general terms

• transmembrane 4 protein

Additional terms

• leptin receptor overlapping transcript-like 1; brain my047 protein (LEPROTL1)
• leptin receptor; LEP-R; OB receptor; OB-R; HuB219; CD295 (LEPR, DB, OBR)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54741
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54741
• OMIM: https://mirror.omim.org/entry/613461
• UniProt: http://www.uniprot.org/uniprot/O15243.html