beta-synuclein (SNCB)

Function

• could act as a regulator of SNCA aggregation
• beta-synuclein is incapable of fibrillogenesis
• protects neurons from staurosporine & 6-hydroxydopamine (6OHDA)-stimulated caspase activation (TP53/p53-dependent)
• contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA
• phosphorylation by G-protein coupled receptor kinases is more efficient than phosphorylation by CK1, CK2 & CaM-kinase 2

Structure

• belongs to the synuclein family
• 61% Identical to alpha-synuclein

Compartment

• cytoplasm
• concentrated in presynaptic nerve terminals

Expression

• expressed predominantly in brain

Pathology

• non-amyloid component of senile plaques found in Alzheimer disease
• SNCB is found in spheroids. but not in inclusions of patients with Hallervorden-Spatz syndrome
• not found in the Lewy bodies associated with Parkinson disease

Comparative biology

• human homolog of bovine phosphoneuroprotein 14

More general terms

• synuclein

Database

• UniProt: http://www.uniprot.org/uniprot/Q16143.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6620
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6620
• OMIM: https://mirror.omim.org/entry/602569