roquin (RING finger & C3H zinc finger protein 1, RING finger protein 198, RC3H1, KIAA2025, RNF198)

Function

• represses ICOS function
• ubiquitin ligase regulating ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD & HUR/ELAVL1
• may bind RNA

Structure

• contains 1 C3H1-type zinc finger
• contains 1 RING-type zinc finger

Compartment

cytoplasm, cytosolic RNA granules

Alternative splicing

named isoforms=2

Expression

• widely expressed
• expressed at higher level in cerebellum, spleen, ovary, liver

More general terms

• ring finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q5TC82.html