CD278; inducible T-cell co-stimulator (ICOS); activation-inducible lymphocyte immunomediatory molecule (AILIM)

Function

• enhances T cell responses to foreign antigen
• interacts with receptor for ICOS ligand

Compartment

membrane & secreted forms

Expression

• activated T cells
• tonsillar T cells
• lower levels in
  • thymus, lymph node, lung, peripheral blood leukocytes

Pathology

• mutations associated with ICOS deficiency, a form of common variable immunodeficiency

More general terms

• CD antigen
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/604558
• OMIM: https://mirror.omim.org/entry/607594
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29851
• UniProt: http://www.uniprot.org/uniprot/Q9Y6W8.html