Flt3-interacting zinc finger protein 1 (zinc finger protein 798, FIZ1, ZNF798)

Function

• transcriptional repressor of NRL function in photoreceptors
• does NOT repress CRX-mediated transactivation
• interacts with FLT3 cytoplasmic catalytic domain, following receptor stimulation, in a kinase-independent manner
  • does not interact with other structurally related receptor tyrosine kinases, including KIT, CSF1R, PDGFR
• interacts with NRL

Structure

• contains 11 C2H2-type zinc fingers

Compartment

cytoplasm, nucleus

Expression

widely expressed

More general terms

• C2H2 type zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96SL8.html