neural retina-specific leucine zipper protein (NRL, D14S46E)

Function

• transcription factor
• regulates expression of several rod-specific genes, including RHO & PDE6B
• interacts with FIZ1
• interaction represses transactivation (putative)

Structure

• belongs to the bZIP family
• contains 1 bZIP domain

Compartment

nucleus

Expression

neural retina

Pathology

• defects in NRL are the cause of retinitis pigmentosa 27

More general terms

• basic leucine zipper (bZIP) family protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4901
• OMIM: https://mirror.omim.org/entry/162080
• UniProt: http://www.uniprot.org/uniprot/P54845.html