Myc-associated zinc finger protein; MAZI; pur-1; purine-binding transcription factor; transcription factor Zif87; ZF87; zinc finger protein 801 (MAZ, ZNF801)

Function

• may function as a transcription factor with dual roles in transcription initiation & termination
• binds to two sites, ME1a1 & ME1a2, within the MYC promoter
  • has greater affinity for ME1a1
• also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors
• interacts with BPTF

Structure

contains 6 C2H2-type Zn+2 fingers

Compartment

• nucleus (probable)

Expression

• present in kidney, liver & brain
• in the brain, highest levels are found in motor cortex & midfrontal cortex (at protein level)

Pathology

• in brains of Alzheimer disease patients, present in plaque-like structures

More general terms

• C2H2 type zinc finger protein
• nuclear protein

Additional terms

• c-myc proto-oncogene protein; transcription factor p64 (c-Myc, MYC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4150
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4150
• OMIM: https://mirror.omim.org/entry/600999
• UniProt: http://www.uniprot.org/uniprot/P56270.html