zinc finger protein 410; zinc finger protein APA-1, another partner for ARF 1 (ZNF410, APA1)

Function

• activates transcription of matrix-remodeling genes including MMP1 during fibroblast senescence
• interacts with CDKN2A/p14ARF
• induced during fibroblast senescence
• sumoylated, sumoylation increases its half-life, via blocking ubiquitin-mediated degradation (putative)

Structure

• contains 5 C2H2-type zinc fingers

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

widely expressed

More general terms

• C2H2 type zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q86VK4.html