zinc finger protein 282; HTLV-I U5RE-binding protein 1; HUB-1 (ZNF282 HUB1)

Function

• binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat
• recognizes the 5'-TCCACCCC-3' sequence as a core motif & exerts a strong repressive effect on HTLV-I LTR-mediated expression

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 5 C2H2-type Zn+2 fingers
• contains 1 KRAB domain

Compartment

nucleus (probable)

Expression

ubiquitous

More general terms

• C2H2 type zinc finger protein
• transcriptional silencer (transcriptional repressor)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8427
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8427
• OMIM: https://mirror.omim.org/entry/603397
• UniProt: http://www.uniprot.org/uniprot/Q9UDV7.html