zinc finger protein 274; neurotrophin receptor-interacting factor homolog; zinc finger protein HFB101; zinc finger protein with KRAB & SCAN domains 19; zinc finger protein zfp2; Zf2 (ZNF274, ZKSCAN19, SP2114)

Function

• probable transcription repressor
• specifically binds to the 3'-end of Zn+2-finger coding genes & recruiting chromatin-modifying proteins such as SETDB1 & TRIM28/KAP1, leading to transcription repression
• interacts with SETDB1 & TRIM28/KAP1

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 5 C2H2-type Zn+2 fingers
• contains 2 KRAB domains
• contains 1 SCAN box domain

Compartment

• cytoplasm (putative)
• nucleus, nucleolus

Alternative splicing

named isoforms=4

More general terms

• C2H2 type zinc finger protein
• transcriptional silencer (transcriptional repressor)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10782
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10782
• OMIM: https://mirror.omim.org/entry/605467
• UniProt: http://www.uniprot.org/uniprot/Q96GC6.html