zinc finger protein 256; bone marrow zinc finger 3; BMZF-3 (ZNF256, BMZF3)

Function

• transcriptional repressor
• role in cell proliferation
• interacts with TRIM28; requires TRIM28 for its activity

Structure

• the KRAB domain mediates interaction with TRIM28 & is required for transcriptional repressor activity
• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 15 C2H2-type Zn+2 fingers
• contains 1 KRAB domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• induced by GDNF/glial cell line-derived neurotrophic factor

More general terms

• C2H2 type zinc finger protein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10172
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10172
• OMIM: https://mirror.omim.org/entry/606956
• UniProt: http://www.uniprot.org/uniprot/Q9Y2P7.html