zinc finger protein 224; bone marrow zinc finger 2; BMZF-2; zinc finger protein 233; zinc finger protein 255; zinc finger protein 27; zinc finger protein KOX22 (ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27)

Function

• may be involved in transcriptional regulation as a transcriptional repressor
• interacts with WT1
• interacts with DEPDC1A

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 18 C2H2-type Zn+2 fingers
• contains 1 KRAB domain

Compartment

• nucleus
• colocalizes with DEPDC1A in the nucleus

Expression

ubiquitous. mainly expressed in fetal tissues

Pathology

• the DEPDC1A-ZNF224 complex may play a role in bladder cancer by repressing transcription of the A20 gene, leading to transport of NF-KB into the nucleus, suppressing apoptosis of bladder cancer cells

More general terms

• C2H2 type zinc finger protein
• phosphoprotein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7767
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7767
• OMIM: https://mirror.omim.org/entry/194555
• UniProt: http://www.uniprot.org/uniprot/Q9NZL3.html