G2/mitotic-specific cyclin-B3 (CCNB3, CYCB3)
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Function
- cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), & thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division
- its tissue specificity suggest that it may be required during early meiotic prophase 1
- interacts with CDK2 kinase
- ubiquitinated (probable)
- ubiquitination leads to its degradation during anaphase entry, after degradation of CCNB1
Structure
- N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin- proteasome pathway (putative)
- belongs to the cyclin family. cyclin AB subfamily
Compartment
Alternative splicing
named isoforms=3
Expression
- testis specific
- in testis, it is expressed in developing germ cells, but not in Leydig cells. weakly or not expressed in other tissues
- G2/M-specific cyclin B3
- maximum concentrations are reached about at the G2/M boundary